Seizures Years Before Alzheimer’s?

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ORLANDO, Fla. (Ivanhoe Newswire) — For years, scientists who study Alzheimer’s disease have acknowledged an increase in seizures in patients- but didn’t focus much attention on them.  That’s changing. New information on the frequency and timing of seizures may give researchers more insight into how the disease can progress.

Scott and Susie Plakon had what Plakon calls a fairytale marriage … but after three decades and six children, the Plakons were dealt a crushing blow.  Doctors diagnosed Susie with Alzheimer’s. She was only 53.

“For several years I couldn’t even tell my kids they were going to lose their mom in 3-5 years, because Alzheimer’s is fatal 100 percent of the time,” Plakon said.

He scaled back his legislative duties to care for Susie until her death in 2018. He says he initially had no idea what Susie would face including sudden, dangerous falls.

Plakon told Ivanhoe, “I found her lying on her side in a seizure state in a pool of blood coming from her head, and I didn’t know what it was.”

“What can happen in the patients with Alzheimer’s disease is essentially a change in the structure of their brain,” Rosemary Lair, MD, MHSA, Med. Dir, Advent Health Maturing Minds Memory Disorder Clinic, said.

Those brain and nerve cell changes can lead to seizures. Now, a study of 300,000 U.S. Veterans over the age of 55 showed seizures were associated with twice the risk for developing dementia between one and nine years later. Doctor Laird was not involved in the newest research, but says at the very least clinicians need to carefully treat seizures and prepare caregivers.

“If the seizures are active enough and disruptive enough or put them at risk to get hurt, you have to kind of prioritize to that,” Dr. Laird said.

Representative Plakon says every scientific finding may bring doctors closer to new treatments- and someday a cure.

“I’m looking forward to that day,” Plakon said.

Representative Plakon continues to honor his late wife Susie by advocating for Alzheimer’s research and working to improve public awareness.

Contributors to this news report include: Cyndy McGrath, Executive Producer; Keon Broadnax, Assistant Producer; Roque Correa, Videographer; Matt Goldschmidt, Editor.

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MEDICAL BREAKTHROUGHS

RESEARCH SUMMARY

 

TOPIC:            SEIZURES YEARS BEFORE ALZHEIMER’S?

REPORT:       MB #4692

BACKGROUND: Alzheimer’s disease is the most common cause of dementia, which is a continuous decline in thinking, behavioral and social skills. Some symptoms are memory loss, making poor choices, not being able to complete everyday tasks anymore, and showing depressed behavior. There is no cure for Alzheimer’s disease, but there are medications that temporarily improve symptoms or slow the rate of decline. These treatments can sometimes help maximize function and maintain independence for a period. If the disease progresses and the brain’s inability to function lead to dehydration, malnutrition or infection, it could result in death.

(Source: https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447 )

DIAGNOSING: Part of diagnosing Alzheimer’s requires an accounting of the symptoms of the person or from a family member or close friend. Doctors run a physical to measure the person’s reflexes, muscles, sight and hearing, and balance and coordination. A blood test may be ordered to simply rule out other potential causes of memory loss, such as vitamin deficiencies and thyroid disorder. Finally, brain scans, like magnetic resonance imaging (MRI) or computerized tomography (CT,) may be run to rule out other head injuries.

(Source: https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/diagnosis-treatment/drc-20350453)

NEW TECHNOLOGY: Recent studies have shown that seizures may be an early indicator for Alzheimer’s disease and precede early signs of memory loss. When there is a change in a brain’s structure, the electrical activity that normally flows through the tissue surface gets excited. If someone has Alzheimer’s, the tissue will degenerate and electrical waves are disrupted, which may develop a kink that becomes a seizure. Rosemary Laird, M.D., Geriatrician with the Advent Health Medical Group, says caregivers should watch for seizure triggers for those affected and that they should help the person stay safe during the seizure. Another suggestion is to make sure patients are taking their medications on time.

(Source: https://www.statnews.com/2019/07/19/alzheimers-role-of-seizures/ )

FOR MORE INFORMATION ON THIS REPORT, PLEASE CONTACT:

Eddie Thompson

Eddie.thompson@myfloridahouse.gov

Gianna Perera

gnperera@alz.org

If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Marjorie Bekaert Thomas at mthomas@ivanhoe.com