A revolutionary DNA search engine is speeding up genetic discovery-Click HereWhy women live longer than men, explained by evolution-Click HereBananas could be ruining your smoothie’s health benefits-Click HereThis easy daily habit cuts heart risk by two thirds-Click HereWeight-loss drugs like Ozempic may also curb drug and alcohol addiction-Click HereLife expectancy gains have slowed sharply, study finds-Click HereHow strong is your weed, really? Scientists say labels often mislead-Click HereMIT scientists discover hidden 3D genome loops that survive cell division-Click HereYou might look healthy, but hidden fat could be silently damaging your heart-Click HereScientists reversed brain aging and memory loss in mice-Click HereSports concussions increase injury risk-Click HereUncovering a cellular process that leads to inflammation-Click HereNew study links contraceptive pills and depression-Click HereA short snout predisposes dogs to sleep apnea-Click HereBuilding a new vaccine arsenal to eradicate polio-Click HereThe Viking disease can be due to gene variants inherited from Neanderthals-Click HereQatar Omicron-wave study shows slow decline of natural immunity, rapid decline of vaccine immunity-Click HereMore than a quarter of people with asthma still over-using rescue inhalers, putting them at increased risk of severe attacks-Click hereProgress on early detection of Alzheimer’s disease-Click HereDried samples of saliva and fingertip blood are useful in monitoring responses to coronavirus vaccines-Click HereDietary fiber in the gut may help with skin allergies-Click HereResearchers discover mechanism linking mutations in the ‘dark matter’ of the genome to cancer-Click HereDespite dire warnings, monarch butterfly numbers are solid-Click HereImmunotherapy may get a boost-Click HereArtificial intelligence reveals a never-before described 3D structure in rotavirus spike protein-Click HereRecurring brain tumors shaped by genetic evolution and microenvironment-Click HereCompound shows promise for minimizing erratic movements in Parkinson’s patients-Click HereConsuming fruit and vegetables and exercising can make you happier-Click HereCOVID-19 slows birth rate in US, Europe-Click HereLink between ADHD and dementia across generations-Click HerePreventing the long-term effects of traumatic brain injury-Click HereStudy details robust T-cell response to mRNA COVID-19 vaccines — a more durable source of protection-Click HereArtificial color-changing material that mimics chameleon skin can detect seafood freshness-Click HereNeural implant monitors multiple brain areas at once, provides new neuroscience insights-Click HereB cell activating factor possible key to hemophilia immune tolerance-Click HereMasks not enough to stop COVID-19’s spread without distancing, study finds-Click HereAI can detect COVID-19 in the lungs like a virtual physician, new study shows-Click HerePhase 1 human trials suggest breast cancer drug is safe, effective-Click HereRe-engineered enzyme could help reverse damage from spinal cord injury and stroke-Click HereWeight between young adulthood and midlife linked to early mortality-Click HereIncreased fertility for women with Neanderthal gene, study suggests-Click HereCoronavirus testing kits to be developed using RNA imaging technology-Click HereFacial expressions don’t tell the whole story of emotion-Click HereAcid reflux drug is a surprising candidate to curb preterm birth-Click HereTreating Gulf War Illness With FDA-Approved Antiviral Drugs-Click HereHeart patch could limit muscle damage in heart attack aftermath-Click HereA nap a day keeps high blood pressure at bay-Click HereIn small groups, people follow high-performing leaders-Click HereTick tock: Commitment readiness predicts relationship success-Click HereA comprehensive ‘parts list’ of the brain built from its components, the cells-Click HereResearchers confine mature cells to turn them into stem cells-Click HereNew tissue-imaging technology could enable real-time diagnostics, map cancer progression-Click HereEverything big data claims to know about you could be wrong-Click HerePsychedelic drugs promote neural plasticity in rats and flies-Click HereEducation linked to higher risk of short-sightedness-Click HereNew 3D printer can create complex biological tissues-Click HereThe creative brain is wired differently-Click HereWomen survive crises better than men-Click HerePrecise DNA editing made easy: New enzyme to rewrite the genome-Click HereFirst Time-Lapse Footage of Cell Activity During Limb RegenerationStudy Suggests Approach to Waking Patients After Surgery

Baby Blues: World’s First Postpartum Pill

0

RALEIGH, N.C. (Ivanhoe Newswire) — It’s known as one of the happiest times in a woman’s life. The birth of her baby. But that’s not the case for every new mom. One in seven moms are overcome with feelings of sadness, worthlessness, guilt and even suicide. Postpartum depression or PPD is on the rise. The CDC found that the rate of depression diagnosed at delivery was seven times higher in 2015 than in 2000. There’s a drug newly approved by the FDA that’s being hailed as a lifesaver for new parents. Baby blues

Little Mave is Brooke Wiesner’s third child and most difficult pregnancy — born four weeks premature.

Brooke says, “I was pretty depressed right afterwards. I didn’t feel about her, like the way I feel, like I should have felt about her.”

Two months after Mave’s birth …

Brooke says, “I had all my kids in the car, and I was like, I have to go to a doctor because I’m like, if my kids weren’t in the car, I don’t know, I might would drive it off the side of the road or something.”

Suicide accounts for about 20 percent of postpartum deaths and is the leading cause of maternal mortality in the US. That’s why the first two FDA approved drugs to treat PPD are literally lifesavers.

Riah Patterson, MD, Psychiatrist at University of North Carolina says, “The idea that we can get people better in a matter of days or weeks is absolutely critical in this really delicate imperative timeframe.”

The first drug – Zulresso– requires a hospital stay and is given by IV for 60 hours. And now, the FDA has approved a pill form – Zurzuvae– that new moms can take over a course of 14 days at home.

Doctor Patterson says, “I see people who have dramatic changes in their mood who at first don’t talk about their family or their baby at all coming into the infusion and by the end are showing me photos.”

Brooke chose the IV version. In the first 24 hours … She says, “I don’t know, I was like super hopeful and then probably 48 hours I like had no feelings of sadness at all.”

And now Brooke is back – being an active, involved, loving mom to Piper, Cole, and Mave.

These two drugs are the first to specifically treat postpartum depression. Data suggests up to 95 percent of women never reach remission as their PPD was not recognized or undertreated. If you are experiencing postpartum depression, you can call or text the international helpline at 1-800-944-4773. If you are having suicidal thoughts right now, call the crisis lifeline at 9-8-8.

Contributors to this news report include: Marsha Lewis, Producer; Bob Walko, Editor, Matt Goldschmidt

Sources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059965/#:~:text=Postpartum%20depression%20is%20one%20of,(prevalence%2010%20–%2015%25)

https://www.marchofdimes.org/find-support/topics/postpartum/postpartum-depression

https://journals.lww.com/greenjournal/Abstract/2019/06000/Recorded_Diagnoses_of_Depression_During_Delivery.20.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976222/#CR1

https://www.psychiatrictimes.com/view/pregnancy-and-postpartum-suicide-risk-the-new-numbers

BEATING BABY BLUES: WORLD’S FIRST POSTPARTUM PILL

REPORT #3175

BACKGROUND: Approximately one in eight women are said to have postpartum depression (PPD) after giving birth. A diagnosis is made if the symptoms last longer than two weeks. PPD is very common and considered a mental health condition that can affect any pregnant woman. Some of the most common signs of PPD are feeling sad, anxious, or overwhelmed. Many women state they don’t feel connected to their baby, and some even say they don’t feel love towards their baby. The most common symptoms of PPD are feeling depressed most of the day every day; feeling shame, guilt, or like a failure; feeling panicked or scared a lot of the time; and having severe mood swings.

(Source: https://www.womenshealth.gov/TalkingPPD?gad_source=1&gclid=CjwKCAjwz42xBhB9EiwA48pT72SHLcWxD1UpEnv1iIEMt1KXjIo5Ey5uSV3oWhNRG8f8oSQkcmw6MRoCb9wQAvD_BwE and https://www.marchofdimes.org/find-support/topics/postpartum/postpartum-depression)

DIAGNOSIS AND TREATMENT: To reach a diagnosis of PPD, a doctor will review with a patient how they are feeling and go over any symptoms being experienced. They could also order a blood test to check hormone levels. Treatment for PPD is very similar to any other depression with the most common being prescription medications and talk therapy. If PPD is severe enough, electroconvulsive (ECT) therapy may be used to treat severe depressions with hallucinations or delusions or overwhelming suicidal thoughts. Medications like antidepressants will help resolve immediate issues like lack of sleep and appetite changes. However, a woman who is breastfeeding must be careful with which antidepressant to take. Talk therapy is the next step in treating PPD. This type of specialist will meet with a patient regularly to help work through feelings and habits. The two types of talk therapy are cognitive behavioral therapy and interpersonal therapy.

(Source: https://familydoctor.org/condition/postpartum-depression/ and https://www.webmd.com/depression/postpartum-depression/understanding-postpartum-depression-treatment)

ADVANCES IN PPD DIAGNOSIS: A study led by Johns Hopkins researchers discovered that communication among cells is altered in pregnant women who develop PPD after giving birth. The study suggests that women who develop PPD are unable to efficiently remove aging and defective cell components. This process is called autophagy and is known to break down in the brain of patients with Alzheimer’s and Parkinson’s disease. “Potentially, postpartum depression could be treated using certain Alzheimer’s and Parkinson’s disease medications that induce autophagy,” says Sarven Sabunciyan, PhD, an assistant professor of pediatrics at the Johns Hopkins University School of Medicine. Researchers agreed that the study was limited by small numbers and a lack of racial diversity. However, if further studies confirm the findings, they could potentially develop a blood test that can identify women who are pregnant and at risk for developing PPD after delivery.

(Source: https://www.hopkinsmedicine.org/news/newsroom/news-releases/2022/10/study-advances-search-for-biological-markers-that-predict-risk-of-postpartum-depression)

* For More Information, Contact: 

 Kendall Daniels, Communication Specialist II

UNC Health and UNC School of Medicine

(804) 337-6072

Kendall.daniels@unchealth.unc.edu

Or visit the UNC Center for Women’s Mood Disorders

At https://www.med.unc.edu/psych/wmd/

Free weekly e-mail on Medical Breakthroughs from Ivanhoe. To sign up: http://www.ivanhoe.com/ftk