The Estrogen Window


BOSTON, Mass. (Ivanhoe Newswire) — In the 1990’s estrogen was the most prescribed medicine in the United States. But in 2002, a study came out saying estrogen hormones caused an increased health risk, causing a lot of concern for women. Now, one researcher says it’s time to rethink hormone therapy during a specific period of time during menopause … more on the estrogen window.

Hot flashes, night sweats, weight gain and more are all uncomfortable symptoms of menopause. For the past decade and a half, many women have shunned hormone replacement therapy after reports that hormones could increase the risk of breast cancer. Dr. Mache Seibel, from Beth Israel Deaconess Medical Center in Boston, says those life-threatening claims were off-base. Dr. Seibel says estrogen replacement therapy, when done at the right time, is safe and highly effective.

“The right time is what I call the estrogen window. And the estrogen window, is a window of time that begins when menopause begins and continues roughly for about ten years,” Mache Seibel, MD, Author of The Estrogen Window and The Estrogen Fix, Beth Israel Deaconess Medical Center, Harvard Medical School, explained. (Read Full Interview)

Karen started hormone replacement therapy a year ago.

“I was having a great deal of brain fog, my skin felt very dry, I was suddenly having weight gain, especially in the middle area,” Karen recalled.

Studies now prove estrogen is both safe and beneficial for most women early in their menopause.

“Estrogen by itself can actually lower the risk of breast cancer by 23 percent. It can lower the risk of heart disease by 32 percent,” Dr. Seibel stated.

Karen said to Dr. Seibel, “I know my long-term health is going to be better and I know I’ll be avoiding potentially some very grave diseases by taking the hormone replacement therapy and the frosting on the cake is that my symptoms go away, so I love that.”

Experts say it’s important to point out that starting estrogen hormones after that ten-year menopausal window has closed might not be as safe. Six thousand women a day go through menopause, equaling two million women a year.

Contributors to this news report include: Pamela Tomlin, Field Producer; Eric Speede, Videographer; Cyndy McGrath, Supervising Producer; Gabriella Battistiol, Assistant Producer; Roque Correa, Editor.

To receive a free weekly e-mail on Medical Breakthroughs from Ivanhoe, sign up at:





REPORT:       MB #4337

BACKGROUND: Menopause marks the end of a woman’s menstrual cycles. It’s diagnosed after a patient has gone 12 months without a menstrual period. Menopause can happen in a person’s forties or fifties; however, the average age in the US is 51. It is a natural biological process; however the physical symptoms may disrupt a person’s sleep, lower their energy and affect their emotional health. In the months or years leading up to menopause when a woman is in perimenopause, they might experience signs and symptoms including irregular periods, vaginal dryness, hot flashes or chills, night sweats, mood changes, weight gain and a slowed metabolism, thinning hair and dry skin, or loss of breast fullness.


ESTROGEN STUDY: In the 1990’s it was common for women to go through estrogen hormone therapy, until a study was published by the Women’s Health Initiative. The estrogen plus progestin trial was stopped in July 2002 after investigators found that the associated health risks of the combination hormone therapy outweighed the benefits. Participants were followed for an average of 5.6 years, and the study claimed estrogen hormones caused breast cancer and other life-threatening diseases.


CONTROVERSY CONTINUES: Dr. Mache Seibel from Beth Israel Deaconess Medical Center in Boston, says those life-threatening claims are surrounded by a lot of confusion and fear. Dr, Seibel believes estrogen replacement therapy, when done at the right time, is safe, highly-effective and can ease the uncomfortable side effects of menopause. The North American Menopause Society also presented this at their annual meeting this year (2017). The right time, as Dr. Seibel calls it, the “Estrogen Window,” is from the time that menopause begins, up until about ten years from this point. Dr. Seibel has written a book, called “The Estrogen Fix,” that explains more about this option for women.

(Source: and Mache Seibel, MD)

MORE FROM DR. SEIBEL: “Early menopause is going into menopause before age 45. It is both safe and effective for that demographic and in fact is rather essential for those women to remain healthy. But the point now proven is that estrogen is both safe and effective for most women early in their menopause – within 10 years of going into menopause or before age 60.”


Teresa Herbert

Mache Seibel


If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Marjorie Bekaert Thomas at

Doctor Q and A

Read the entire Doctor Q&A for Mache Seibel, MD

Read the entire Q&A