Reported July 2006

BACKGROUND: Cornell University medical engineer Michael Shuler, Ph.D., has developed a "body on a chip" that can take the place of the human body when it comes to testing new drugs or cosmetics. The chip would also make it easier to customize drug treatments for patients. Incorporating cells from a patient into the chip would help physicians determine which option would work best.

IMPROVED DRUG DESIGN: A drug's effect depends less on what it's made of than on the way it navigates through the body: being broken down by the liver, absorbed by the intestines, and stored in fat cells. There are more than 10,000 possible drug compounds, and it can be difficult to determine which combinations are the most promising investments. Currently, only about one-tenth of the drugs that go through human trials find their way into marketable products. The body on a chip could reduce the need for animal testing, and do a better job of steering the right drugs to human trials. This would make it cheaper to develop drugs while increasing the number of effective drugs that reach the market each year.

HOW IT WORKS: Tiny "labs-on-a-chip" have been on the market for several years, but thus is the first that essentially functions as a living body. Normally, cells grown in the lab don't work quite the same outside the body as they do inside the body, making it difficult to effectively simulate responses. The device is the size of a postage stamp and is etched with chambers and channels lined with living tissue. When pumped through with artificial blood laced with test drugs, this "torso-on-a-chip" can highlight both harmful and beneficial effects other tests miss.

ABOUT MICROFLUIDICS: Microfluidics studies how fluids behave at microscopic levels: volumes of water, for example, that are thousands of times smaller than a single droplet. At these size scales, tiny effects that wouldn't be noticeable on a large scale play a much larger role. By understanding these effects, scientists can use them manipulate fluids on the microscopic scale. This has led to such beneficial technologies as ink jet printers and labs-on-a-chip for fast and cheap DNA sequencing.

If you would like more information, please contact:

Department of Biomedical Engineering & Chemical and Biomolecular Engineering
Cornell University
Ithaca, NY
(607) 255-1003
biomedeng@cornell.edu

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