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General Health Channel
Reported July 11, 2014

Down Syndrome: The Key To Alzheimer's?

San Diego (Ivanhoe Newswire) — More than five million Americans are living with Alzheimer’s. More than 400,000 of them also have Down syndrome. What does a condition seen at birth have in common with a disease typically diagnosed in the elderly? Quite a bit!

Jonathan Shirley has Down syndrome, but he’s never let what he can’t do hold him back.  “I don’t look at disabilities at all. I look at what I can do.” Shirley told Ivanhoe.

Jerry Shirley, his dad, says Jonathan’s always finding ways to help others. “Jonathan is an amazing guy. He’s been an inspiration.” He said.

Shirley is now helping doctors at the University of California San Diego not only learn more about his condition but also about Alzheimer’s disease.

 “These individuals, when they hit the age of 40, 100 percent of them have the pathological changes of Alzheimer’s disease in their brain.” Dr. Michael Rafii, MD, PhD, neurologist at UCSD told Ivanhoe.

As part of a clinical trial, Dr. Rafii has found Down syndrome brains look very much like Alzheimer’s brains. Both have higher levels of the protein beta amyloid. In fact, Down syndrome patients develop the protein at double the rate.

“We may be able to translate those discoveries into therapies for the general population… People with Down syndrome represent the world’s largest population of predetermined Alzheimer’s disease from a genetic perspective.”  Rafii said.

61 year old Lisa Goldberg has Down syndrome and her sister says she is now showing some signs of dementia also.

 “Something that happened five minutes ago, it’s hit or miss whether she recalls.”  April Hinson, Goldberg’s sister told Ivanhoe.

Goldberg still works and doesn’t let her disability get in her way.

And Shirley agrees…“We are all special in our own way.”

It just may be that Down patients like Shirley and Goldberg hold the key to finding the answer to Alzheimer’s.

Dr. Rafii’s research is now focusing on how somebody can have amyloid plaques in their brain and have full dementia, whereas someone else has the same amyloid plaque but no dementia.  Rafii believes there is something some patients have in their brains that makes them resilient to it.  MORE.

More Information                                                                                                     

Click here for additional research oDown Syndrome: The Key To Alzheimer's?.

Click here for Ivanhoe's full-length interview with Dr. Michael Raffi.

If this story or any other Ivanhoe story has impacted your life or prompted you or someone

you know to seek or change treatments, please let us know by contacting Marjorie Bekaert

Thomas, mthomas@ivanhoe.com.

 

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