Cognition may be aided by Pro-Inflammatory
(Ivanhoe Newswire) – A small amount of a pro-inflammatory protein may actually help cognition, according to research from the University of Texas Health Center.
Although inflammation is believed to be responsible for a variety of diseases, researchers were able to show low levels of the protein interleukin-6 are important in a key kind of cognition called reversal learning. This kind of learning is diminished in many psychiatric diseases like depression, schizophrenia, and post-traumatic stress disorder. Researchers blocked interleukin-6 in the brains of stressed-induced rats, and found this hampered their cognitive ability. But when they restored the protein to the brain, the cognitive deficit disappeared.
“We’ve replicated just one piece of a very complex disease so we can understand the biology,” senior study author David Morilak, PhD, was quoted as saying. “There’s still a lot of work to do.”
For more information, go to: http://uthscsa.edu/hscnews/singleformat2.asp?newID=4707
SOURCE: Journal of Neuroscience, January 2014
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