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General Health Channel
Reported December 12, 2013

Acid-reducing Meds Linked to Vitamin B12 Deficiency

(Ivanhoe Newswire) – A new study from Kaiser Permanente, Oakland, Calif., finds that patients using proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) for two or more years, may experience a vitamin B12 deficiency.

If not treated, the deficiency may cause the patient to have neurologic damage, anemia, or dementia. Douglas A. Corley, MD, PhD, of the Kaiser Permanente Division of Research along with colleagues conducted a study of 25,956 patients who had a vitamin B12 deficiency. Their findings showed that 12 percent of patients who used protein pump inhibitors for two years had a significant deficiency of vitamin B12.

"Patients who took PPI medications for more than two years had a 65 percent increase in their risk of B12 deficiency. Higher doses also were associated with an increased risk, compared with lower doses. Kaiser Permanente's electronic health records allowed us to look at what happens in the real world for these commonly used medications," Dr. Corley was quoted as saying.

For more information, go to: http://media.jamanetwork.com/news-item/acid-suppressing-medications-associated-vitamin-b12-deficiency/

SOURCE: Journal of the American Medical Association, December 2013

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