Cancer Cells ‘Hide’ from Treatment
(Ivanhoe Newswire) – Brain cancer cells reduce gene mutation exposure when they sense treatments aimed to seek these cells out, and then increase expression after it senses treatments are gone.
Researchers at the University of California, San Diego investigated the behavior of glioblastoma multiforme, the most common type of malignant brain cancer in adults, which has an average survival time of 14 months. They found that cancer cells dump their growth inhibitor, called EGFRvIII, when they sense the presence of treatment targeting that inhibitor. When the treatment disappears, the growth inhibitor reappears in the cells at normal levels and continues growth.
"This discovery has considerable clinical implications because if cancer cells can evade therapy by a 'hide-and-seek' mechanism, then the current focus (of drug therapies) is unlikely to translate into better outcomes for patients," study lead Paul S. Mischel, MD, was quoted as saying.
For more information, go to: http://health.ucsd.edu/news/Pages/default.aspx
SOURCE: Science, December 2013
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