Striking Differences in Molecular Basis of Each Alzheimer Patient
(Ivanhoe Newswire) – Thread-like protein deposits in the brain is identified as Alzheimer’s disease to doctors, but now studies are showing that this may vary for patients.
The molecular structure of the beta-amyloid fibrils is not well-known and this may be a determining factor of the degree of brain damage. "This detailed structural model may be used to guide the development of chemical compounds that bind to these fibrils with high specificity for purposes of diagnostic imaging, as well as compounds that inhibit fibril formation for purposes of prevention or therapy,” senior study author Robert Tycko of the National Institutes of Health. Tycko, was quoted as saying.
Researchers found that fibrils in the brain of Alzheimer patients have structural variations that could relate to their analytic history. "Our study also shows that certain fibril structures may be more likely than others to cause Alzheimer's disease, highlighting the importance of developing imaging agents that target specific fibril structures to improve the reliability and specificity of diagnosis,” Tycko was quoted as saying.
For more information, go to: http://www.cell.com/cellpress
SOURCE: Cell Press, September 2013
Click Here for a free weekly email with Ivanhoe's latest Medical Breakthroughs.