Probability of Cancer Detected on First Screening CT
(Ivanhoe Newswire) –Major issues in the implementation of screening for lung cancer by means of low-dose computed tomography (CT) are the definition of a positive result and the management of lung nodules detected on the scans. Researchers have conducted a population-based prospective study to determine factors predicting the probability that lung nodules on the first low-dose CT scans are malignant or will be on follow-up.
Researchers used two data sets. The rates of cancer in the two data sets were 5.5 percent and 3.7 percent. Predictors of cancer included older age, female sex, emphysema, family history of lung cancer, larger nodule size, part-solid nodule type, location of the nodule in the upper lobe, lower nodule count, and spiculation. Researchers found that predictive tools based on patient and nodule characteristics can be used to accurately estimate the probability that lung nodules detected on baseline screening low-dose CT scans are malignant.
For more information, go to: http://www.nejm.org/doi/full/10.1056/NEJMoa1214726
SOURCE: New England Journal of Medicine, September 2013
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