Single Protein Found in Nearly All Brain Tumors
By Evan Wofford, Ivanhoe Health Correspondent
(Ivanhoe Newswire) – Nearly 100 percent of high-grade brain tumors share a single protein, according to researchers from Johns Hopkins University.
After identifying which protein was turned on most frequently in 18 tissue samples of meningioma, the most common form of brain cancer, the research team looked for the protein expression in 110 tissue samples. The protein was found in 108 of the samples, and the expression is associated with higher disease and mortality rates in the patients the tissue came from. The protein was already the subject of a clinical trial at the National Cancer Institute (NCI).
The belief is that the protein will become the target of specific treatment in the future. “Our hope is now the medical community will recognize that the most difficult to treat meningiomas might be eligible for this clinical trial at the NCI, and that other immunotherapy scientists and researchers might consider designing similar trials to benefit this class of patients,” Gregory J. Riggins, M.D., and lead author of the study, told Ivanhoe.
For more information, go to; http://www.hopkinsmedicine.org/news/media/releases/johns_hopkins_researchers_find_promising_therapeutic_target_for_hard_to_treat_brain_tumor
SOURCE: Cancer Immunology Research, August 2013
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