New Method for Combating Parkinson's Disease
(Ivanhoe Newswire) -- Researchers have brought new clarity to the picture of what goes awry in the brain during Parkinson's disease and have identified a compound that eases the disease's symptoms in mice.
In the new study, researchers from Johns Hopkins collaborated with the National Cancer Institute to develop mice whose genes for a protein called AIMP2 could be switched into high gear. The consequences were that the mice developed symptoms similar to those of Parkinson's as they aged.
The researchers used a compound that would block a protein called PARP1; they tested it on mice with too much AIMP2. "Not only did the compound protect dopamine-making neurons from death, it also prevented behavioral abnormalities similar to those seen in Parkinson's disease," graduate student Yunjong Lee was quoted as saying.
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SOURCE: Nature Neuroscience, August 2013
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