Hormones and Microbes Protect Males from Autoimmune Diseases?
(Ivanhoe Newswire) – The relationship between gut microbes and sex hormones in males can help protect them from autoimmune diseases, which could explain the gender bias in these diseases.
Researchers at the University of Chicago studied microbial communities in male and female mice, finding that these became different when the animals reached puberty. However, the communities in females were more similar in castrated male mice.
"The gender bias in major autoimmune diseases is well known, but not well understood," senior study author Alexander Chervonsky was quoted as saying. "By studying how microbes cooperate with hormones to affect the immune system, we can identify pathways that can be triggered artificially by drugs or manipulations of gut microbes to interfere with the course of autoimmunity."
For more information, go to: http://www.cell.com/immunity/abstract/S1074-7613%2813%2900341-5
SOURCE: Immunity, August 2013
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