Overlap Between the "Big Five" Mental Disorders
(Ivanhoe Newswire) --The largest genome-wide study of its kind has determined how much five major mental illnesses are traceable to the same common inherited genetic variations.
Researchers found that the overlap was highest between schizophrenia and bipolar disorder; moderate for bipolar disorder and depression and for ADHD and depression; and low between schizophrenia and autism. Overall, common genetic variation accounted for 17-28 percent of risk for the illnesses.
The newfound molecular genetic evidence linking schizophrenia and depression, if replicated, could have important implications for diagnostics and research, say the researchers. The study results also attach numbers to molecular evidence documenting the importance of heritability traceable to common genetic variation in causing these five major mental illnesses.
For more information go to: http://www.nimh.nih.gov/health/publications/publications-in-english.shtml
SOURCE: Nature Genetics, August 2013
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