Safer Treatments for Arthritis
(Ivanhoe Newswire) -- Arthritis drugs have long been associated with potentially fatal cardiovascular side-effects in patients, including strokes, but now there is some good news. Researchers at the Imperial College in London have possibly discovered a way to avoid this potentially deadly side affect.
Drugs such as Vioxx, diclofenac, ibuprofen, and Celebrex operate by blocking an enzyme known as COX-2, whose presence in blood vessels has up until now been held responsible for these side effects. New research carried out on mice has revealed that COX-2 is largely absent from the major blood vessels and instead found in the brain, gut, and kidney as well as the thymus gland in the chest, where it may well be affecting the cardiovascular health.
Now that researchers know where in the body the drug is acting, they can begin to develop safer, more targeted drugs for patients with arthritis as well as cancer.
For more information go to: http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_3-7-2013-14-15-27
SOURCE: PLOS ONE, July 2013
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