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Breast Cancer Channel
Reported June 20, 2013

New Molecular Pathway Increases Breast Cancer Risk!

(Ivanhoe Newswire) – New research has identified a new molecular pathway involving the gene ZNF356.  Researchers also found that the abnormalities in that pathway may predict worse outcomes for patients with breast cancer. 

“Genomic instability is an increased tendency for abnormal changes in DNA, like the addition of extra copies of chromosomes, DNA breaks and mutations. Because these genetic abnormalities increase the chances for developing a tumor, it is fundamentally important to understand the molecular basis of genomic instability in cancer for prognosis and therapy,” Ji-Hye Paik, PhD, Assistant Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York, N.Y., was quoted as saying.  

Researchers demonstrated that p53 activates ZNF365 to maintain genomic stability.  They found that cells deficient in ZNF365 showed signs of incomplete doubling of DNA, which caused abnormal cell division and unequally divided chromosomes.  Also, researchers concluded that because ZNF365 promotes the timely resolution of cell division, its loss led to an abnormal number of chromosomes (aneuploidy).

For more information, go to: http://www.aacr.org/home/public--media/aacr-in-the-news.aspx?d=3120

SOURCE: Cancer Discovery, June 2013

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