Signals Behind Transplant Rejection Revealed
(Ivanhoe Newswire) – A new study led by Fadi Lakkis from University of Pittsburgh showed that the immune system is signaled to reject a transplanted organ when T cells, the immune cells that mediate rejection, encounter immune-stimulating proteins called antigens that are expressed by the transplanted organ.
Before this study, it was believed that for the T-cells to migrate to the transplanted organ they had to initially be activated by chemokines, a kind of molecule. Using mice, researchers were able to prove contact with chemokine is not necessary for T-cell migration. This new information could help with the development of future anti-rejection therapies.
For more information, go to http://www.jci.org/articles/view/66722?key=5debbc8dd29fc8e22b12.
SOURCE: Journal of Clinical Investigation, May 2013
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