Bypassing Blocked Arteries to Grow New Ones
(Ivanhoe Newswire) – Researchers from the Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes, and other acute illnesses bypassing arteries that are blocked.
Working with mice, the Yale-UCL team discovered that in order for VEGF- a molecular signal that organs release -- driven artery formation to occur, VEGF must bind with two molecules known as VEGFR2 and NRP1, and all three must work as a team. Corresponding author Michael Simons, Professor of Medicine and Cell Biology, and Director of the Cardiovascular Research Center at Yale School of Medicine, was quoted as saying, "this (discovery) opens new therapeutic opportunities for developing drugs that would either stimulate or inhibit blood vessel formation — important goals in cardiovascular and anti-cancer therapies, respectively."
For more information, go to: http://news.yale.edu/2013/04/29/growing-new-arteries-bypassing-blocked-ones.
SOURCE: Developmental Cell, May 2013
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