Obesity Causes Chronic Kidney Disease?
(Ivanhoe Newswire) — In 2008, more than 1.4 billion adults worldwide were overweight, with approximately 500 million of them being obese, according to the World Health Organization. Obesity in young adulthood may significantly increase individuals' risks of developing kidney disease by the time they become seniors. The findings emphasize the importance of excess weight as a risk factor for chronic kidney disease (CKD).
Richard Silverwood, PhD, Dorothea Nitsch, MD (London School of Hygiene & Tropical Medicine, in England), and their colleagues conducted a study to see what sort of effect being overweight or obese might have on kidney health.
The researchers analyzed information from the Medical Research Council National Survey of Health and Development, a sample of children born in one week in March 1946 in England, Scotland, and Wales. A total of 4,584 participants had available data, including body mass index at ages 20, 26, 36, 43, 53, and 60 to 64 years.
Participants who were overweight beginning early in adulthood (ages 26 or 36 years) were twice as likely to have CKD at age 60 to 64 years compared with those who first became overweight at age 60 to 64 years or never became overweight. Larger waist-to-hip ratios ("apple-shaped" bodies) at ages 43 and 53 years were also linked with CKD at age 60 to 64 years.
"We estimated that 36 percent of CKD cases at age 60 to 64 in the current U.S. population could be avoided if nobody became overweight until at least that age, assuming the same associations as in the analysis sample," Dr. Nitsch, was quoted as saying. "To our knowledge we are the first to report how age of exposure to overweight across adulthood may affect kidney disease risk," she added.
It is unclear whether the timing of overweight onset or the duration of being overweight drives the link with CKD seen in the study. Either explanation suggests that preventing excess weight gain in early adulthood could have a considerable effect on the prevalence of CKD. Doing so appears to have a larger effect than any treatment for CKD known to date, the researchers said.
SOURCE: Journal of the American Society of Nephrology (JASN), April 2013