Detecting Lung Congestion Before Symptoms Rise

(Ivanhoe Newswire) -- Asymptomatic lung congestion increases dialysis patients' risks of dying prematurely or experiencing heart attacks or other cardiac events. However, a new technique can help detect the congestion, which may help improve cardiovascular health and prevent deaths in dialysis patients.

Lung congestion due to fluid accumulation is highly prevalent among kidney failure patients on dialysis, but it often doesn't cause any symptoms. To see whether such asymptomatic congestion affects dialysis patients' health, Carmine Zoccali, MD (Ospedali Riuniti, Reggio Calabria, Italy) and his colleagues measured the degree of lung congestion in 392 dialysis patients by using a very simple and inexpensive technique: lung ultrasound.

The lung ultrasound revealed very severe congestion in 14% of patients and moderate-to-severe lung congestion in 45% of patients. Among those with moderate-to-severe lung congestion, 71% were asymptomatic. When these patients were compared with those having mild or no congestion, those with very severe congestion had a 4.2-fold increased risk of dying and a 3.2-fold increased risk of experiencing heart attacks or other cardiac events over a two-year follow-up period.

Asymptomatic lung congestion detected by lung ultrasound was a better predictor of patients' risk of dying prematurely or experiencing cardiac events than symptoms of heart failure.

The findings indicate that assessing subclinical pulmonary edema can help determine dialysis patients' prognoses. "More importantly, our findings generate the hypothesis that targeting subclinical pulmonary congestion may improve cardiovascular health and reduce risk from cardiovascular death in the dialysis population, a population at an extremely high risk," Dr. Zoccali was quoted as saying. Fluid in the lungs may be reduced with longer and/or more frequent dialysis.

Investigators will soon start a clinical trial that will incorporate lung fluid measurements by ultrasound and will test whether dialysis intensification in patients with asymptomatic lung congestion can prevent premature death and reduce the risk of heart failure and cardiac events.

SOURCE: Journal of the American Society of Nephrology, March 2013

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