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Advances in health and medicine.
Marjorie Bekaert Thomas
Advances in health and medicine.
Women's Health Channel
Reported December 25, 2012

Estrogen to Fight Brain Aneurysms?

CHICAGO, Ill. (Ivanhoe Newswire) - In the heads of millions of Americans, they sit silently and can burst without warning. Brain aneurysms rupture in about 30,000 people every year, killing or disabling many. Women are at a higher risk for aneurysms than men. Now, researchers are taking a closer look at how a major change in a woman’s life could be to blame.

“The left side of my body got numb,” explains Sande Skinner, a woman who once had a brain aneurysm. “It didn’t feel right.”

Sande Skinner thought she was having a stroke.

“It’s a giant aneurysm,” said Skinner. “The little sucker was right behind my right optic nerve.”

If ruptured, brain aneurysms can lead to stroke or death. Risk factors include smoking, high blood pressure and possibly lower estrogen levels caused by menopause. Two of the largest brain aneurysm trials in the world found most happen in menopausal women.

“Average age of rupture of all patients with aneurysms is age 52, which just so happens to be the average age of menopause,” Michael Chen, M.D., a Neurointerventionalist at Rush University Medical tells Ivanhoe.

Dr. Michael Chen says severe drops in estrogen may contribute to the weakening of artery walls. He conducted a study of 60 women with aneurysms and found compared to the general population, they were less likely to have taken birth control or to be on hormone replacement therapy. He believes estrogen treatments could help prevent women from developing aneurysms. 

“Protect them from the effects of these severe changes and hormones on their blood vessels,” explains Dr. Chen. 

Now, the doctor is enrolling a new trial to put his theory to the test. He’ll use low-dose hormone replacement therapy in pre-menopausal women in hopes of stopping aneurysms from forming.

After three surgeries and several stents, Sande’s aneurysm is no longer a threat.

“I’m still walking and talking,” said Skinner. 

The doctor hopes his research will help wipe out the threat for every woman.

Dr. Chen’s study will start off with about 40 to 50 women with treated and untreated aneurysms. He hopes it will eventually expand into a multi-center trial around the country. Go to our website for more information on how to participate.

For additional research on this article, click here.

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 If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Andrew McIntosh at

For More Information, Please Contact:

Deb Song, Associate Director of Media Relations
Rush University Medical Center
(312) 942-0588

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