Medical Breakthroughs Reported by Click here to go to the homepage.
Be the First to Know. Click here to subscribe FREE!
Search Reports: Use quotation marks around your multi-word search terms in the box below to perform search of
Advances in health and medicine.Use " marks around search terms
What's New
News Flash
  Alternative Health
Asthma & Allergies
Breast Cancer
Cardiovascular Health
Children's Health
Dental Health
Fertility & Pregnancy
Men's Health
Mental Health
Multiple Sclerosis
Neurological Disorders
Nutrition & Wellness
Pet Health
Seniors' Health
Sports Medicine
Women's Health
Advances in health and medicine.
Click here to sign up for Medical Alerts!
Click below to access other news from Ivanhoe Broadcast News.
  Click here to get Ivanhoe's Medical Headline RSS feed Click here to listen to Ivanhoe's Medical Podcasts
Useful Links
Play It Again, Please
E-Mail a Friend
Order Books Online
Inside Science
Smart Woman
Advances in health and medicine.
Smart Woman Home
Click here to read the story
Click here to read the story
Click here to read the story
Smart Woman Home
Advances in health and medicine.
Click below to learn about Ivanhoe.
About Us
Contact Us
Ivanhoe FAQ
Our TV Partners
Travel Calendar
Advances in health and medicine.
Ivanhoe celebrates 20 years of medical news reporting reaching nearly 80 million TV households each week. Click here to learn more...
Advances in health and medicine.
Marjorie Bekaert Thomas
Advances in health and medicine.
Women's Health Channel
Reported November 26, 2012

Spotted! New Therapeutic Targets for Ovarian Cancer


(Ivanhoe Newswire) — From harmless to deadly – normal cells surrounding ovarian cancer cells can be changed to promote tumor growth. Now, a new understanding of what causes this switch may provide researchers with therapeutic targets to battle the deadly disease.
"New approaches for treating patients with ovarian cancer are desperately needed," said Ernst Lengyel, M.D., Ph.D., professor in the department of obstetrics and gynecology at the University of Chicago. 
"There have been no new approaches introduced into the clinic for quite some time, and we have seen no major improvements in patient survival over the years."
So Lengyel and his colleagues set out to learn how normal stromal cells are transformed into cancer-associated fibroblasts, which are found in the tissue immediately surrounding the ovarian cancer cells.
"The strength of our study lies in the fact that we used cells from patients, rather than cell lines," Lengyel said. "This means that our model system reflects as closely as possible the clinical situation in patients."
The data indicated that cancer-associated fibroblasts from patients with ovarian cancer had abnormal patterns of expression of small molecules called microRNAs compared with normal and tumor-adjacent fibroblasts.
MicroRNAs are regulators of gene expression and help direct cell function, meaning modified patterns of microRNA expression change cell function.
Lengyel and colleagues further studied the microRNA most upregulated, or increased in quantity, in cancer-associated fibroblasts, and the two microRNAs most significantly downregulated. They then changed the pattern of expression of these three microRNAs to mimic the pattern they had seen in cancer-associated fibroblasts. They found that the normal fibroblasts were converted into cells with characteristics of those associated with cancer. In addition, the cells had reprogrammed by altering microRNA expression and enhanced the growth of tumor cells in a mouse model of ovarian cancer.
Restoring the pattern of expression of the three microRNAs to normal in cancer-associated fibroblasts reduced their cancer-promoting characteristics.
"Our work suggests that it might be possible to modify microRNA expression in cancer-associated fibroblasts for therapeutic benefit," Lengyel said. "Therapeutic approaches targeting microRNAs in cancer cells are under development."
Treatments targeting microRNAs in cancer-associated fibroblasts may be particularly effective because the cells are genetically stable. Cancer cells are not. Therefore, the risk that cancers will become unresponsive to the treatments is less likely than it is for treatments targeting cancer cells, Lengyel said.
Source: Cancer Discovery, a journal of the American Association for Cancer Research
Related Articles in Latest Medical News:

[ Back to Women's Health Channel Home ]

Stay up to date on Women's Health. We can notify you every time there is a medical breakthrough. Click here to sign up.
Most Recent Videos

Follow Us On:

Click here to go to Ivanhoe's Twitter page Click here to go to Ivanhoe's Facebook page Click here to go to Ivanhoe's YouTube page

How to Find a Qualified Mammography Provider

For the nearest FDA-certified mammography provider, or to check the status of your imaging center, call the NCI's CIS at (800) 4-CANCER.


Home | What's New | News Flash | Search/Latest Medical News | E-Mail Medical Alerts!
Ivanhoe FAQ | Privacy Policy | Our TV Partners | Awards | Useful Links | Play It Again, Please
RSS Feeds | Advertising/Sponsorships | Content Syndication | Reprints

Advances in health and medicine.
Copyright © 2016 Ivanhoe Broadcast News, Inc.
2745 West Fairbanks Avenue
Winter Park, Florida 32789
(407) 740-0789

P.O. Box 865
Orlando, Florida 32802

Premium Content in Latest Medical News Denotes Premium Content in Latest Medical News