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Reported November 7, 2012

Survival Climbs, Unnecessary Shock Plummets

 

(Ivanhoe Newswire) – Each year, about 100,000 defibrillators are implanted into patients in the United States. In people who truly need them, defibrillators can be life saving. But researchers are finding that when set too low, they are shocking hearts that do not need shocking.
 
A new study shows that defibrillators – devices designed to detect and correct dangerous heart rhythms – can help people with heart disease live longer, and with a much better quality of life, than they do now.
 
A small, very simple change in the way physicians set or programmed the device led to a dramatic 80 to 90 percent reduction in inappropriate therapies – potentially painful and anxiety-provoking shocks delivered for rhythms that aren't dangerous or life threatening. The new programming also significantly increased survival, lowering the risk of death by 55 percent compared to patients whose devices used traditional programming. This reduction is above and beyond the usual decrease in mortality associated with defibrillator therapy, leading to an overall 70 percent reduction in death.
 
The team found that simply raising the heart rate at which the device is set to fire deliver therapy, made all the difference.
 
"The way we've been using implantable defibrillators for the last 20 years has really been less than optimal," Professor Arthur J. Moss, M.D., a world-renowned expert in the treatment and prevention of cardiac arrhythmias and sudden cardiac death, was quoted saying.
 
 "The extent to which the new programming reduced death and inappropriate therapies was quite striking and has the potential to beneficially affect a wide spectrum of patients who are at risk for sudden death or rhythm disorders," Moss added.
 
Implantable cardioverter defibrillators or ICDs constantly monitor the rate and rhythm of the heart and are supposed to deliver electrical shocks in response to very fast and potentially fatal heart rhythms. In 2002, Moss and the MADIT (Multicenter Automatic Defibrillator Implantation Trial) research group showed that ICDs are extremely effective in preventing death in patients at risk of irregular heart rhythms and sudden cardiac death, including individuals who've suffered a heart attack. The work changed medical guidelines nationwide, making thousands of heart attack survivors eligible for ICD therapy. Currently, around 200,000 ICDs are implanted in the U.S. every year.
 
But, according to a 2008 study, approximately 20 to 25 percent of defibrillator therapy is inappropriate, meaning shocks are delivered in response to less dangerous rhythms that aren't likely to pose any immediate danger to patients. Such shocks are not only painful, but can take an emotional toll as well. Data from a 2002 trial comparing anti-arrhythmic drugs and defibrillators suggested that shocks are associated with reduced mental well-being. A recent review of more than 45 studies found that such emotional distress is not uncommon, reporting that between 11 and 28 percent of ICD patients had some form of depression and between 11 and 26 percent had an anxiety disorder.
 
Moss' team conducted the MADIT-RIT (Reduce Inappropriate Therapy) trial to determine if different ways of setting the device – a complex process performed by a heart rhythm specialist prior to device implantation in a patient's chest – could reduce the occurrence of inappropriate therapy. 
 
From September 2009 through October 2011 the team enrolled 1,500 patients in 98 hospital centers in the United States, Canada, Europe, Israel, and Japan. All patients had heart disease and received a Boston Scientific ICD or CRT-D.
 
Currently, most defibrillators are set to initiate therapy when the heart rate exceeds around 170 beats per minute, but rates of 180 or 190 are not always dangerous, are usually short-lived, and could be related to increased activity or exercise. Unfortunately, Moss says, defibrillators aren't very good at differentiating benign from malignant rhythms in this "in-between" range.
 
Setting the device to fire at a higher rate of 200 beats per minute reduced the risk of experiencing a first inappropriate therapy by 79 percent compared to standard programming. Fewer shocks also corresponded with less energy delivered to the heart, which study authors believe contributed to the reduced risk of death.
 
"There is considerable research to suggest that there is a small amount of damage to the heart muscle with each delivered shock. If we can eliminate the unnecessary shocks, this is going to be associated with less heart damage and improved outcomes," Moss added. 
 
The MADIT-RIT trial is the first large-scale, randomized study designed to evaluate specific programming features to reduce inappropriate therapy in patients with ICDs. 
 
"When the findings were first uncovered there was a sincere, general enthusiasm that we had finally come to improve the therapy we've been using for 20 years, and that we've made true progress in making ICD therapy safer, more effective, and more acceptable to patients," Moss concluded.
 
Source: The American Heart Association’s Scientific Sessions 2012, November 2012 
 

 

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