Medical Breakthroughs Reported by Ivanhoe.com. Click here to go to the homepage.
Be the First to Know. Click here to subscribe FREE!
Search Reports: Use quotation marks around your multi-word search terms in the box below to perform search of Ivanhoe.com.
Advances in health and medicine.Use " marks around search terms
 
What's New
News Flash
Discussion
healthchannelnews
  Alternative Health
Arthritis
Asthma & Allergies
Autism
Breast Cancer
Cancer
Cardiovascular Health
Children's Health
Dental Health
Diabetes
Fertility & Pregnancy
Men's Health
Mental Health
Multiple Sclerosis
Neurological Disorders
Nutrition & Wellness
Orthopedics
Pet Health
Robotics
Seniors' Health
Sports Medicine
Vision
Women's Health
Advances in health and medicine.
Click here to sign up for Medical Alerts!
Click below to access other news from Ivanhoe Broadcast News.
  Click here to get Ivanhoe's Medical Headline RSS feed Click here to listen to Ivanhoe's Medical Podcasts
Useful Links
Play It Again, Please
E-Mail a Friend
Order Books Online
Inside Science
Smart Woman
Advances in health and medicine.
Smart Woman Home
Click here to read the story
Click here to read the story
Click here to read the story
Smart Woman Home
Advances in health and medicine.
Click below to learn about Ivanhoe.
  Awards
About Us
Contact Us
Employment
Feedback
Ivanhoe FAQ
Our TV Partners
Travel Calendar
Advances in health and medicine.
Ivanhoe celebrates 20 years of medical news reporting reaching nearly 80 million TV households each week. Click here to learn more...
Advances in health and medicine.
Marjorie Bekaert Thomas
Publisher/President
Advances in health and medicine.
Advertisement
General Health Channel
Reported November 1, 2012

Human-like Mice Livers Enhance Drug Development


(Ivanhoe Broadcast)—A new bioengineering technique that substitutes human liver cells in place of mice liver cells may allow researchers to develop more effective drugs prior to clinical trials. Stanford scientists evaluated mice with “humanized’ livers in the search for a potent hepatitis C drug cocktail. Over 150 million people are infected with HVC, the virus that causes hepatitis C and is the leading cause of liver transplant and liver cancer.

Researchers wanted to target HVC while overcoming obstacles of past mice drug testing. Unfortunately, the previous standard does not allow scientists to account for the interaction of multiple drugs and the metabolic functional differences between mouse and human livers.

"This gives us a new tool for improving the testing of drugs before they are given to people in clinical trials," the study's senior author, Gary Peltz, MD, PhD, professor of anesthesiology, pain and perioperative medicine said in a previously prepared statement. “All too often, drugs showing tremendous promise in preclinical animal assessments fail in human trials because of unforeseen safety problems. It's often not the drug itself, but one of its metabolites, that is responsible for a drug-induced toxicity."

The HVC trial drug, clemizole was tested using the modified mouse livers in an effort to develop a cheap, effective alternative to severe, costly treatments currently on the market.  Though prescribed as an antihistamine in the 1950s and 1960s, clemizole is being repurposed to target the HVC virus while interacting safely with other prescriptions—30 percent of the population 57 years and older take five prescriptions or more.

The mice livers were altered by researchers by killing liver cells and replacing them with human liver cells. The chimeric mice used in testing had varying levels of human cell integration. The study authors were able to distinguish how the human cells were interacting with drugs versus the mice cells and concluded that the bioengineered mice were accurate indicators of human performance and that clemizole is a viable drug for HVC trials.

The enhanced mice showed researchers effects that were previously masked due to the inherent differences in organ structure or created false alarms when transferred from mice to human candidates. The novel testing holds promise for future drug development targeting a plethora of additional ailments.

Source: Journal of Pharmacology and Experimental Therapeutics.
 

Want to be the FIRST TO KNOW?

Click Here for a free weekly email with Ivanhoe's latest Medical Breakthroughs.

 

Related Articles in Latest Medical News:

[ Back to General Health Channel Home ]

MEDICAL ALERT!
Stay up to date on General Health. We can notify you every time there is a medical breakthrough. Click here to sign up.
EDITOR'S CHOICE
Most Recent Videos
Your Baby DVD
What Every Pregnant Woman Should Know

Happier Woman DVD
25 ways to reduce stress

Forever Young DVD
25 ways to lose 10 years

Feel Good Again DVD
25 ways to STOP THE PAIN

If a treatment you read about here helps you, let us know...Click here!!

Follow Us On:

Click here to go to Ivanhoe's Twitter page Click here to go to Ivanhoe's Facebook page Click here to go to Ivanhoe's YouTube page

Scale
Do you know if you are height-weight proportional?

Find out your Body Mass Index (BMI).

Click Here

Advertisement

How safe are your dietary supplements?

Click here to find out with the FDA's list of supplements and drug interactions.

Home | What's New | News Flash | Search/Latest Medical News | E-Mail Medical Alerts!
Ivanhoe FAQ | Privacy Policy | Our TV Partners | Awards | Useful Links | Play It Again, Please
RSS Feeds | Advertising/Sponsorships | Content Syndication | Reprints

Advances in health and medicine.
webdoctor@ivanhoe.com
Copyright © 2014 Ivanhoe Broadcast News, Inc.
2745 West Fairbanks Avenue
Winter Park, Florida 32789
(407) 740-0789

P.O. Box 865
Orlando, Florida 32802

Premium Content in Latest Medical News Denotes Premium Content in Latest Medical News