Medical Breakthroughs Reported by Ivanhoe.com. Click here to go to the homepage.
Be the First to Know. Click here to subscribe FREE!
Search Reports: Use quotation marks around your multi-word search terms in the box below to perform search of Ivanhoe.com.
Advances in health and medicine.Use " marks around search terms
 
What's New
News Flash
Discussion
healthchannelnews
  Alternative Health
Arthritis
Asthma & Allergies
Autism
Breast Cancer
Cancer
Cardiovascular Health
Children's Health
Dental Health
Diabetes
Fertility & Pregnancy
Men's Health
Mental Health
Multiple Sclerosis
Neurological Disorders
Nutrition & Wellness
Orthopedics
Pet Health
Robotics
Seniors' Health
Sports Medicine
Vision
Women's Health
Advances in health and medicine.
Click here to sign up for Medical Alerts!
Click below to access other news from Ivanhoe Broadcast News.
  Click here to get Ivanhoe's Medical Headline RSS feed Click here to listen to Ivanhoe's Medical Podcasts
Useful Links
Play It Again, Please
E-Mail a Friend
Order Books Online
Inside Science
Smart Woman
Advances in health and medicine.
Smart Woman Home
Click here to read the story
Click here to read the story
Click here to read the story
Smart Woman Home
Advances in health and medicine.
Click below to learn about Ivanhoe.
  Awards
About Us
Contact Us
Employment
Feedback
Ivanhoe FAQ
Our TV Partners
Travel Calendar
Advances in health and medicine.
Ivanhoe celebrates 20 years of medical news reporting reaching nearly 80 million TV households each week. Click here to learn more...
Advances in health and medicine.
Marjorie Bekaert Thomas
Publisher/President
Advances in health and medicine.
Advertisement
General Health Channel
Reported October 3, 2011

New Animal Model for Autism

By Alicia Rose DelGallo, Ivanhoe Health Correspondent

(Ivanhoe Newswire) -- Mice with a single defective gene are showing striking parallels to humans with autism. According to a study published in the September 30th issue of Cell, a Cell Press publication, the mouse model offers several promising discoveries.

The study involved developing mice lacking CNTNAP2, a rare variant of the gene that has been shown to cause a form of autism known as cortical dysplasia-focal epilepsy syndrome (CDFE).

Researchers found that the animals displayed very similar behaviors of human autism. Not only were they hyperactive, they suffered epileptic seizures, repetitive behaviors, and abnormal social interaction.

The study also revealed a closer look at the animals' brains, which showed problems in the development of the neural circuitry, including abnormal migration of neurons, abnormal activity of the neural network, and fewer interneurons that connect neurons carrying impulses to the central nervous system with those sending them to the rest of the body.

These observations are consistent with emerging theories that autism is characterized in the brain with "long-range disconnectivity and short-range increases in connectivity," according to Geschwind.

So, why is this new animal model for autism important? In addition to providing verification of the gene's association with autism, the study also provides insight into the biological mechanism that underlies the disease, as well as new ways to test and develop treatments.

"To develop new drugs, it is critical to have good animal models," said author Daniel Geschwind of the University of California, Los Angeles.

Mice carrying the defective gene responded well to treatment with risperidone, an antipsychotic drug, and the first approved by the FDA for treating symptoms of autism.

According to the author, animals given the drug were less hyperactive, showed less repetitive grooming behavior and were better at building nests. However, they did not show any improvement in social interactions. All of these reactions are consistent with those of human patients taking the drug.

"I did not necessarily expect to see the same behaviors in mice as in humans because we don't know how conserved the pathways are. This suggests they are very conserved- surprisingly so," Geschwind was quoted as saying.

He adds that the findings are a big step towards developing new drugs and strategies for treating autism.

SOURCE: Cell, published online Thursday September 29, 2011; phone interview with Dr. Daniel Geschwind conducted on Wednesday September 28 at 11:15 am EST.

To Receive Med Alerts all year click here.

 

Related Articles in Latest Medical News:

[ Back to General Health Channel Home ]

MEDICAL ALERT!
Stay up to date on General Health. We can notify you every time there is a medical breakthrough. Click here to sign up.
EDITOR'S CHOICE
Most Recent Videos
Your Baby DVD
What Every Pregnant Woman Should Know

Happier Woman DVD
25 ways to reduce stress

Forever Young DVD
25 ways to lose 10 years

Feel Good Again DVD
25 ways to STOP THE PAIN

If a treatment you read about here helps you, let us know...Click here!!

Follow Us On:

Click here to go to Ivanhoe's Twitter page Click here to go to Ivanhoe's Facebook page Click here to go to Ivanhoe's YouTube page

Scale
Do you know if you are height-weight proportional?

Find out your Body Mass Index (BMI).

Click Here

Advertisement

How safe are your dietary supplements?

Click here to find out with the FDA's list of supplements and drug interactions.

Home | What's New | News Flash | Search/Latest Medical News | E-Mail Medical Alerts!
Ivanhoe FAQ | Privacy Policy | Our TV Partners | Awards | Useful Links | Play It Again, Please
RSS Feeds | Advertising/Sponsorships | Content Syndication | Reprints

Advances in health and medicine.
webdoctor@ivanhoe.com
Copyright © 2014 Ivanhoe Broadcast News, Inc.
2745 West Fairbanks Avenue
Winter Park, Florida 32789
(407) 740-0789

P.O. Box 865
Orlando, Florida 32802

Premium Content in Latest Medical News Denotes Premium Content in Latest Medical News